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Sunday, December 6, 2015
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Syros Pharmaceuticals today announced the results of new preclinical
studies in which SY-351, one of its first-in-class selective
cyclin-dependent kinase 7 (CDK7) inhibitors, was observed to have
significant anti-tumor activity, including inducing and maintaining
complete tumor regression, in in vivo models of acute leukemias. About Levitra (Vardenafil) with free Rx
These data are being presented at the American Society of Hematology
(ASH) Annual Meeting.
“Our CDK7 inhibitor program highlights the power of our gene control
platform to selectively target transcription and potentially treat
diseases that so far have been underserved by other genomic-based
approaches,” said Nancy Simonian, M.D., Chief Executive of Syros. About Micardis Hct (Telmisartan - Hydrochlorothiazide) with free prescription
“People with acute leukemias often face a grim prognosis, and there has
been little improvement in treatment options for these patients. About Hair Loss Cream () with no Rx Using
our platform, we have created potent and selective CDK7 inhibitors that
have been shown to alter the levels of cancer-contributing genes with
the potential to deliver a profound and durable clinical benefit for
these patients.”
In the preclinical studies presented at ASH, Syros’ potent and selective
CDK7 inhibitor was observed to preferentially kill cancer cells over
normal cells and induce tumor regression in patient-derived xenograft
models of acute myeloid leukemia (AML) and acute lymphoblastic leukemia
(ALL). Buy Ipsita without Rx In the in vitro and in vivo studies, SY-351 was
observed to induce:
Complete tumor regression in 100 percent of mice treated with a 5
mg/kg dose in patient-derived xenograft models of AML and ALL, which
was sustained for 30 days following the end of treatment.
Rapid induction of cell death in AML and ALL cell lines, killing 75
percent of cancer cells within 48 hours, while inducing little to no
cell death in normal cells.
Potent and selective inhibition of CDK7, with limited off-target
inhibition when profiled across a panel of 468 kinases.
Minimal effect on blood cells, including white blood cells, platelets,
lymphocytes, neutrophils and reticulocytes, suggesting a more
favorable profile than less selective compounds that inhibit multiple
members of the CDK family.
Significant repression of Myb, a transcription factor known to play a
key role in AML.
Certain cancers, including AML, ALL, small cell lung cancer, triple
negative breast cancer and MYCN-amplified neuroblastoma, are dependent
on high and constant expression of transcription factors for their
growth and survival, and have been shown to be particularly sensitive to
selective inhibition of CDK7. Breast Success () with no prescription Syros is developing potent and highly
selective CDK7 inhibitors with enhanced drug-like properties over SY-351.
About Syros PharmaceuticalsSyros Pharmaceuticals is a
biopharmaceutical company applying a pioneering approach to discover and
develop medicines that control the expression of genes with the aim of
treating cancer and other serious diseases. Buy Improve Memory online Syros has built a
proprietary gene control platform that provides the Company with a
unique lens to identify crucial genes that become dysregulated in
diseased cells. http://webmdconsult.wordpress.com Syros is leveraging its platform to develop a pipeline
of gene control product candidates that it believes will provide a
profound and durable benefit for patients. The Company’s scientific
founders are world-class leaders in gene control research and
translation. Launched by Flagship Ventures and ARCH Venture Partners,
Syros Pharmaceuticals is located in Cambridge, Mass.
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