Half of breast cancers 'could be slowed with a common hormone'

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Poor education is a 'killer on a par with continued smoking'

. About Combivent with no Rx Mortality attributable to low education "is comparable in magnitude to mortality attributable to individuals being current rather than former smokers," concludes a study published in PLoS ONE. More recent generation showed greater death rate disparity related to education. The conclusion adds: "Existing research suggests that a substantial part of the association between education and mortality is causal." The authors say that increasing levels of education could significantly reduce adult death rates in the US. The mechanisms cited by which higher educational attainment is linked to reduced death risk include: Higher income and social status Enhanced cognitive development Adherence to medical treatments Healthier behaviors Improved social connections and psychological wellbeing. Dr. About Cartia Xt (Diltiazem Hcl) with free Rx Buy Bactrim (Trimethoprim And Sulfamethoxazole) with no prescription Virginia Chang, associate professor of population health at New York University School of Medicine, says: "In public health policy, we often focus on changing health behaviors such as diet, smoking and drinking. Education - which is a more fundamental, upstream driver of health behaviors and disparities - should also be a key element of US health policy." The authors conclude: "Our results suggest that policies and interventions that improve educational attainment could substantially improve survival in the US population, especially given widening educational disparities across birth cohorts." The researchers used data from the National Health Interview Survey carried out by the Centers for Disease Control and Prevention. Data enabling an estimate of the number of deaths attributed to low levels of education were available on more than a million people from 1986 to 2006. Buy Niacin online About Vermox (Mebendazole) The team studied people born in 1925, 1935 and 1945 to look at changes over the generations. The results showed that 145,243 deaths could have been saved in the 2010 population if adults who had not completed high school went on to earn a General Educational Development or high school degree. This figure was comparable to the estimated number of deaths that could be averted if all current smokers had the mortality rates of former smokers. The team also estimated that 110,068 deaths could be saved if adults with some college education went on to complete a bachelor s degree. Growing disparity The differences in death rates across different levels of education grew substantially over time, say the researchers. For example, mortality rates fell modestly among those with high school degrees, but much more rapidly among those with college degrees. http://webmd-review.blogspot.com Nimotop (Nimodipine) with free Rx Therefore, encouraging adults who have not finished high school to do so could save twice as many lives among those born in 1945 compared with the generation born in 1925. Patrick Krueger, PhD, assistant professor in the department of health and behavioral sciences at the University of Colorado Denver, says: "Our results suggest that policies and interventions that improve educational attainment could substantially improve survival in the US population, especially given widening educational disparities. "Unless these trends change, the mortality attributable to low education will continue to increase in the future." Written by Markus MacGill

Molecule found that helps BRCA gene resist cancer treatment

. http://pharmaceuticaljournal.wordpress.com n a new study they report in the journal Molecular Cell, scientists describe how they identified a small molecule that helps the BRCA2 gene do its job. Buy Aricept (Donepezil) with free Rx BRCA2 is a tumor suppressor gene that can cause breast and ovarian cancers in as many as 60% of women whose form of this gene is mutated. The researchers say understanding how cancer cells repair DNA breaks will help develop new ways to counter resistance to chemotherapy. Like normal cells, cancer cells need to repair DNA to survive. About Vigora (Sildenafil Citrate) without Rx This is somewhat of a paradox - in their case, they are concerned with maintaining the integrity of "faulty" DNA. DNA repair in cells - both healthy and cancerous - is controlled by genes, including BRCA genes. Decades ago, scientists discovered that variants of BRCA1 and BRCA2 genes are markers for increased risk of breast cancer. Buy Starlix (Nateglinide) with no prescription According to the National Cancer Institute, together, BRCA1 and BRCA2 mutations account for about 20-25% of hereditary breast cancers and about 5-10% of all breast cancers. Co-betaloc In addition, mutations in these genes account for around 15% of all ovarian cancers. Breast and ovarian cancers involving BRCA1 and BRCA2 mutations tend to develop earlier in life than their non-hereditary counterparts. BRCA mutations are also known to play a role in prostate and pancreatic cancers. While chemotherapy drugs can be effective for fighting cancer in people with BRCA mutations, there is a tendency for the cancer to develop resistance to the drugs. About Cialis Jelly (Tadalafil) with free prescription The BRCA proteins develop secondary mutations that continue to promote cancer growth. Findings point to a way to counter drug resistance in BRCA cancers Now, scientists at Yale School of Medicine in New Haven, CT, have pinpointed a key molecule called co-factor DSS1 that helps the BRCA2 gene to repair DNA. They note how "DSS1 acts as a DNA mimic," and without it, BRCA2 mutations cannot do their job of repairing DNA - which is key to the survival of cancer cells. The team says the findings point to a possible way to decrease drug resistance in cancers involving BRCA genes. Senior author Patrick Sung, a professor of molecular biophysics and biochemistry, suggests drugs that interfere with DSS1 function could be developed and used with existing drugs to overcome this resistance, and explains: "We can design specific targets for drug development only if we fully understand the key players and how they work in the pathway for repairing DNA breaks." Grants from the National Institutes of Health helped fund the study. Meanwhile, Medical News Today recently learned about new research that suggests daily aspirin may prevent breast cancer development and recurrence. Buy NAC online Researchers writing in the journal Laboratory Investigation describe how daily low-dose aspirin almost halved tumor growth in mice with breast cancer. Written by Catharine Paddock PhD

Could eye color predict the risk of alcohol dependence?

. Diamox (Acetazolamide) with free Rx esearchers from the University of Vermont in Burlington have suggested a somewhat surprising way to identify a person s risk of alcohol dependence: eye color. Researchers suggest people with light-colored eyes - particularly those with blue eyes - may be at higher risk for alcohol dependence. Their study, published in the American Journal of Medical Genetics: Neuropsychiatric Genetics (Part B), suggests people with light-colored eyes are more likely to be alcohol dependent than those with brown eyes, with blue-eyed individuals at highest risk. The research team - led by Arvis Sulovari, a doctoral student in cellular, molecular and biomedical sciences, and Dawei Li, assistant professor of microbiology and molecular genetics - says their study is the first to make such an association. According to the National Institute on Alcohol Abuse and Alcoholism, around 16.6 million adults and almost 700,000 youths in the US had an alcohol use disorder in 2013. Buy Low Carb online Buy Sildalis (Sildenafil + Tadalafil) without prescription Each year, nearly 88,000 people die from alcohol-related causes, making it the third leading preventable cause of death in the US. Sulovari, Li and their team note that previous research in individuals of European ancestry has shown that people with light-colored eyes tend to consume more alcohol than those with dark-colored eyes, but they note that no studies had investigated whether there is a link between eye color and alcohol dependence. Genetic link between eye color and alcoholism To find out, the researchers analyzed information from a clinical and genetic database of more than 10,000 people who had been diagnosed with at least one psychiatric illness, including depression, schizophrenia, bipolar disorder and drug or alcohol dependence. "These are complex disorders," says Li. http://webmd-consult.blogspot.com About Alesse (Levonorgestrel Bp + Ethinylestradiol Bp) with no Rx "There are many genes, and there are many environmental triggers." The team included 1,263 alcohol-dependent Americans with European ancestry in their final analysis, and assessed the genetic samples of each individual. The results revealed that individuals with light-colored eyes - particularly those with blue eyes - were at higher risk of alcohol dependence than people with brown eyes. Claritin (Loratadine) without Rx These results remained after being retested three times, accounting for subjects age, gender, ethnicity and geographical location. Commenting on the findings, Sulovari says: "This suggests an intriguing possibility - that eye color can be useful in the clinic for alcohol dependence diagnosis." In addition, the team identified associations between genes related to eye color and genes related to alcohol dependence. Ciplar-LA with free Rx "We found evidence of linkage disequilibrium between an alcohol dependent-associated GABA receptor gene cluster, GABRB3/GABRG3, and eye color genes, OCA2/HERC2, as well as between alcohol dependent-associated GRM5 and pigmentation-associated TYR," they explain. The team says the mechanisms underlying the link between eye color and alcohol dependence are unclear, and more studies are needed to better understand the association. Still, they suggest their results may help uncover the genetic roots of alcoholism as well as other psychiatric disorders. Last month, Medical News Today reported on a study published in JAMA Psychiatry, in which researchers claim 1 in 3 Americans are affected by alcohol use disorders in their lifetime. Written by Honor Whiteman

The largest international study to compare brain volumes of people with major depression to those of healthy people finds the former tend to have a significantly smaller hippocampus. The study found people with major depression had a smaller hippocampus - largely accounted for by the high percentage of participants with recurrent depression. Major depression is a serious mood disorder that affects around 1 in 6 people during their lifetime. When it occurs, persistent feelings of sadness, frustration, loss or anger disrupt everyday life and can endure for weeks, months or even years. The hippocampus - whose name comes from the Ancient Greek word for "seahorse" because of its shape - is an area of the brain that, among other things, is associated with forming new memories. Buy Viagra Professional (Sildenafil Citrate) with no prescription The ENIGMA study researchers, including a group from the Brain and Mind Research Institute (BMRI) at the University of Sidney in Australia, suggest their findings highlight a need to treat depression when it first occurs - especially in adolescents and young adults. For the global study - which brings together 15 data sets from Europe, the USA and Australia - the team analyzed magnetic resonance imaging (MRI) brain scans of nearly 9,000 participants: 1,728 with major depression and 7,199 healthy individuals. They also had access to clinical records of the participants with depression. The researchers report their findings in the journal Molecular Psychiatry. Smaller hippocampus largely accounted for by recurrent depression The study has two main findings. Artane (Trihexyphenidyl) with free Rx The first - which confirms earlier clinical work at the BMRI - is that people with major depression have a smaller hippocampus. The second finding is that the first finding is largely accounted for by people with recurrent depression - they represented 65% of the major depression participants. Recurrent depression is a form of major depression where the depressive episodes come back regularly, interspersed with periods of no depression. Another interesting finding is that people whose major depression started before they reached the age of 21 also had a smaller hippocampus. About Pletal (Cilostazol) without Rx The researchers suggest this is consistent with the idea that many of these youngsters go on to have recurrent depression. However, participants who had not experienced more than one episode of major depression - 34% of those with major depression - did not have a smaller hippocampus than the healthy subjects. Jim Lagopoulos, an associate professor at BMRI, says these findings reveal new information about our brain structures and the mechanisms that might underlie depression. Chloromycetin without Rx He adds: "Despite intensive research aimed at identifying brain structures linked to depression in recent decades, our understanding of what causes depression is still rudimentary." He says one reason we know so little about this is the lack of studies with sufficiently large numbers of participants. About ED Super Advanced Pack () with free Rx Another reason is the disease varies widely, as do the treatments, and there are also complex interactions between some of the clinical characteristics and brain structure. Support for neurotrophic hypothesis of depression Co-author Ian Hickie, professor and co-director of BMRI, says the clinical implications of the findings are that we probably need to treat first episodes of depression effectively, "particularly in teenagers and young adults, to prevent the brain changes that accompany recurrent depression." He says there is also a clear need for studies that can track changes in hippocampus size over time in people with depression. Buy Lecithin online Results from such studies would help to clarify the question of cause and effect, "whether hippocampal abnormalities result from prolonged duration of chronic stress, or represent a vulnerability factor for depression, or both." Prof. http://medicalquestionanswers.wordpress.com Lagopoulos also suggests the study lends support to the "neurotrophic hypothesis of depression," the idea that people with chronic depression have certain differences in brain biology - such as sustained higher levels of glucocorticoid - that shrink the brain. Meanwhile, Medical News Today recently learned about new research that suggests brain inflammation links chronic pain with depression. The study is the first to discover brain inflammation caused by chronic nerve pain can affect signaling in regions associated with mood and motivation. Written by Catharine Paddock PhD

What is lysergic acid diethylamide (LSD)? Effects and hazards of LSD

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